Disseminated adenovirus infection in a 10-year-old renal allograft recipient

Disseminated adenovirus infection in a 10-year-old renal allograft recipient

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Disseminated adenovirus infection can result in high mortality and morbidity in immunocompromised patients.Here, we report the case of a 10-year-old renal allograft recipient who presented with hematuria and dysuria.Adenovirus was isolated from his urine.His urinary symptoms decreased after intravenous hydration and reduction of immunosuppressants.However, 2 weeks later he presented with general weakness and laboratory tests indicated renal click here failure necessitating emergency hemodialysis.

Adenovirus was detected in his sputum; therefore, intravenous ganciclovir and immunoglobulin therapy were initiated.Renal biopsy revealed diffuse necrotizing granulomatous tubulointerstitial nephritis compatible with renal involvement of the viral infection.Adenovirus was detected in his serum.Despite cidofovir administration for 2 weeks, adenovirus was also detected in the cerebrospinal fluid, resulting in generalized old taylor whiskey 1933 price tonic-clonic seizure.The patient died 7 weeks after the onset of urinary symptoms.

Adenovirus should be considered in screening tests for post-renal transplantation patients who present with hemorrhagic cystitis.